PD451 - COFFEE AND TEA CONSUMPTION, SARCOPENIA RISK, AND MULTI-OMICS SIGNATURES

PD451

COFFEE AND TEA CONSUMPTION, SARCOPENIA RISK, AND MULTI-OMICS SIGNATURES

X. Liu^1,*, Y. Zhao¹, Y. Li¹, N. Chen¹, T. Liang¹, J. Cui¹

¹The First Hospital of Jilin University, Changchun, China

Rationale: Dietary factors represent modifiable targets for prevention, yet the associations of habitual coffee and tea consumption with sarcopenia risk—and the molecular pathways mediating such associations—remain poorly characterized.

Methods: This prospective cohort study included 445,101 participants from the UK Biobank, followed for a median of 12.2 years. Sarcopenia was diagnosed according to the EWGSOP2 criteria. Coffee and tea consumption was assessed via baseline questionnaire. Cox proportional hazards models with progressive covariate adjustment estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analyses characterized dose–response relationships. Proteomic and metabolomic profiling was performed comparing high (≥4 cups/day) versus low (<4 cups/day) consumers. Functional enrichment analyses were conducted on differentially expressed proteins.

Results: During follow-up, 3,548 incident sarcopenia cases were identified. Compared with non-consumers, intake of 2–3 cups/day of coffee conferred the greatest risk reduction (fully adjusted OR = 0.75, 95% CI: 0.69–0.83, P < 0.001). RCS analyses revealed a non-linear, U-shaped relationship for coffee (P for non-linearity < 0.001), with maximal protection at approximately 3–4 cups/day. Proteomic analyses identified distinct coffee-related (ALPP, LAMP3, CXCL17 upregulated) and tea-related (TNFRSF4, TNFRSF9, CXCL17 upregulated) protein signatures. Metabolomic profiling revealed that VLDL particles and triglycerides were positively associated with sarcopenia risk.

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Conclusion: Habitual coffee and tea consumption are associated with a reduced risk of incident sarcopenia in a dose-dependent manner. Integrated proteomic and metabolomic analyses implicate shared inflammatory, extracellular matrix, and lipid metabolic pathways as potential mediators. These findings support the role of habitual beverage consumption in sarcopenia prevention.

Disclosure of Interest: None declared