PW18 - ASSOCIATION BETWEEN CALF CIRCUMFERENCE AND APPENDICULAR LEAN SOFT TISSUE IN PATIENTS WITH COLORECTAL CANCER

PW18

ASSOCIATION BETWEEN CALF CIRCUMFERENCE AND APPENDICULAR LEAN SOFT TISSUE IN PATIENTS WITH COLORECTAL CANCER

B. C. Santos^1,*, K. L. Ford¹, M. B. Sawyer², C. F. Trottier¹, S. Ghosh², N. E. Deutz³, M. Siervo⁴, M. C. Gonzalez⁵, C. M. Prado¹

¹Department of Agricultural, Food & Nutritional Sciences, ²Department of Oncology, University of Alberta, Edmonton, Canada, ³Center for Translational Research in Aging & Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, United States, ⁴School of Population Health, Curtin University, Perth, Australia, ⁵Postgraduate Program in Nutrition and Food, Federal University of Pelotas, Pelotas, Brazil

Rationale: Calf circumference (CC) is increasingly recognized as a simple, surrogate marker of low muscle mass. Recently, adjustments for body mass index (BMI) have been proposed to improve its accuracy by accounting for excess adiposity. We examined associations between raw and BMI-adjusted calf circumference (r-CC and a-CC) with a more commonly used muscle mass estimation method.

Methods: Baseline data from a clinical trial (Protein Recommendation to Increase Muscle - PRIMe) including patients recently diagnosed with stage II-IV colorectal cancer (CRC) were analyzed. CC (r-CC and a-CC), appendicular lean soft tissue (ALST, via dual-energy X-ray absorptiometry) and ALST adjusted by body weight (ALST/BW) were assessed. Spearman correlation coefficients were calculated.

Results: Among 43 patients (62.8% male, median age 58 [12] years, BMI 26.7 [7.9] kg/m²), low ALST was identified in 18.6%, while low r-CC and a-CC were observed in 9.3 and 23.3%, respectively. r-CC correlated moderately with ALST (ρ=0.664, p<0.001) and showed no correlation with ALST/BW (ρ=0.023, p=0.886), while a-CC had a low correlation with ALST (ρ =0.453, p=0.002) and moderate correlation with ALST/BW (ρ=0.523, p<0.001). When considering patients with BMI ≥25 kg/m² (n=26), correlations with ALST and ALST/BW were stronger for a-CC (ρ=0.658, p<0.001; ρ=0.602, p=0.001) in comparison to r-CC (ρ=0.554, p=0.003; ρ=0.157, p=0.443), respectively.

Conclusion: In patients with CRC, a-CC showed moderate correlation with both ALST and ALST/BW. Using a-CC improved the correlation between this surrogate marker and ALST in patients with overweight or obesity.

Disclosure of Interest: B. Santos: None declared, K. Ford Other: Speaker engagement for: Abbott Nutrition, M. Sawyer Other: Speaker Engagement for Viatris, C. Trottier: None declared, S. Ghosh: None declared, N. Deutz: None declared, M. Siervo: None declared, M. C. Gonzalez Consultant for: Nestle Health Science Brazil, Other: Speaker engagement for Nutricia and Abbott, C. Prado Consultant for: Abbott Nutrition, Nutricia, Novo Nordisk, Other: Speaker engagement for: Abbott Nutrition, Nutricia, Nestle Health Science, Novo Nordisk