P821 - IMPACT OF NUTRITIONAL SUPPORT ON PATIENTS WITH ISCHEMIC STROKE AT ALL STAGES OF REHABILITATION. STUDY TO EVALUATE THE EFFECTIVENESS OF NUTRITIONAL SUPPORT ALGORITHM FOR PATIENTS AFTER STROKE AT ALL STAGES OF REHABILITATION COMPARED TO OTHER COMPLETE DIETS

P821

IMPACT OF NUTRITIONAL SUPPORT ON PATIENTS WITH ISCHEMIC STROKE AT ALL STAGES OF REHABILITATION. STUDY TO EVALUATE THE EFFECTIVENESS OF NUTRITIONAL SUPPORT ALGORITHM FOR PATIENTS AFTER STROKE AT ALL STAGES OF REHABILITATION COMPARED TO OTHER COMPLETE DIETS

N. Egofarov^1,*, G. E. Ivanova², N. A. Shamalov³ on behalf of Tatyana Novikova, Tatyana Lavrova

¹Medical &MAX Director, Nutricia, LLC, ²Head of the Department of Medical Rehabilitation, Russian National Research Medical University named after N.I. Pirogov, ³Director of the Institute, Institute of Cerebrovascular Pathology and Stroke of the Federal Center for Brain and Neurotechnology, Moscow, Russian Federation

Rationale: Up to 62% of pts with dysphagia suffer from malnutrition in the acute and early subacute stages of disease. Recovery of motor functions is most significant in first 90d. Malnutrition worsens the overall prognosis for survival and functional recovery

Methods: 90 pts were divided into 2 groups: study group (SG) of 60 pts, control group (CG) of 30 pts. SG received NS from 1 to 30d. After discharge, SG was randomly divided into 2 subgroups and received nutrition for 60d: subgroup 1 (n = 32) received additional NS in form of dry mixture of 300 kcal/day or in combination with thickener in presence of dysphagia, subgroup 2 (n = 28) received usual diet or in combination with thickener in presence of dysphagia. CG received any products used for 90d at all stages of rehabilitation, upon discharge – ordinary diet

Results: SG experienced significantly less weight loss vs CG (p<0,05). Increase in Rivermead index was higher in SG vs CG (p=0.019), subgroup 1 showed a higher increase vs to subgroup 2 (p=0.049), indicating an advantage of longer-term use of NS. Statistically differences were found between CG and SG in mean change from baseline in Total Protein, Serum Albumin and ALC data, indicating the benefits of NS during 90d observation period. Hand grip dynamometry test demonstrated positive dynamics in SG by V3 (p<0,05). QoL was increased in both groups with faster increase in SG (p<0,05). Barthel Index: 37% of pts in SG were able to care for themselves independently w/o assistance by end of study. In CG none of pts were able to do w/o external assistance of varying degrees (p<0,05)

Conclusion: nutritional support in first 90d has a positive effect on functional recovery of patients after stroke

Disclosure of Interest: N. Egofarov: None declared, G. Ivanova: None declared, N. Shamalov Grant / Research Support from: Principal Investigator in clinical study supported by Nutricia