P392 - ACUTE INTESTINAL FAILURE IN ARGENTINA: A MULTICENTER COHORT STUDY

P392

ACUTE INTESTINAL FAILURE IN ARGENTINA: A MULTICENTER COHORT STUDY

A. L. N. Martinuzzi^1,*, E. Quesada², I. Aversa³, V. Gonzales⁴, E. Manrique⁵, A. Dietrich², C. Galletti⁴, F. Lipovetsky⁶, S. Chapela⁷

¹NUTRITION, NUTRIHOME SA, Neuquén, ²NSU, SANATORIO JUAN XXIII, General Roca, ³NSU, SANATORIO SAN LUCAS, BUENOS AIRES, ⁴NSU, SANATORIO ALLENDE, ⁵NSU, Hospital Privado Universitario de Cordoba, CORDOBA, ⁶Nutrición, UAI, Ciudad Autónoma de Buenos Aires, ⁷NUTRITION, HOSPITAL BRITANICO, BUENOS AIRES, Argentina

Rationale: Acute intestinal failure (AIF) is a critical condition requiring parenteral nutrition (PN) due to compromised nutrient absorption. Limited data exist on its epidemiology and management in Argentina. This study aimed to determine the incidence, causes, and clinical outcomes of AIF in intensive care units (ICUs).

Methods: This multicentre, prospective, observational study included ICU patients diagnosed with AIF and requiring PN between June and November 2023. Demographic, clinical, and nutritional data were collected. Patients were classified as AIF Type I (short-term, self-limiting) or Type II (prolonged, requiring multidisciplinary care). Outcomes included PN-related complications, hospital and ICU length of stay (LOS), and mortality.

Results: Among 2,704 ICU admissions, 81 patients (2.9%) developed AIF (29.9 cases per 1,000 ICU admissions). Type I AIF was more common (55.6%), with patients being younger (p = 0.044) and having lower comorbidity scores (p = 0.043). Type II AIF required longer PN support (median 19 vs. 9 days, p = 0.001) and had higher ICU (p = 0.499) and hospital LOS (p = 0.048). Catheter replacement events were significantly higher in Type II (p = 0.044). Mortality was 24.7%, higher in Type II patients (p = 0.004). A total of 19.4% of AIF type II discharged patients required home PN.

Conclusion: This is the first study to report AIF epidemiology in Argentina. Type II AIF patients had more severe disease, prolonged PN dependency, and worse outcomes. Early identification, individualized nutritional strategies, and structured transitional care are essential to optimize management.

References: Carlson GL, Dark P. Acute intestinal failure. Curr Opin Crit Care 2010;16:347–52. https://doi.org/10.1097/MCC.0b013e328339fabe.

Reintam A, Ploegmakers I, Benoit M, Holst M, Hojgaard H, Burgos R, et al. Acute intestinal failure : International multicenter point-of-prevalence study 2019:1–8. https://doi.org/10.1016/j.clnu.2019.01.005.

Disclosure of Interest: None declared