P934 - CARBOHYDRATE METABOLISM DYSREGULATION AND INFLAMMATION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: AN EXPLORATORY STUDY

P934

CARBOHYDRATE METABOLISM DYSREGULATION AND INFLAMMATION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: AN EXPLORATORY STUDY

E. J. Nava-González^1,*, A. I. Borja-Magno², M. S. Chavero-Torres¹

¹Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, ²Universidad Intercontinental, México, Mexico

Rationale: Women with polycystic ovary syndrome (PCOS) are at increased risk for glucose intolerance, type 2 diabetes, and cardiovascular disease. 

Methods: Ten women aged 20 to 35 years with PCOS, without another disease, were recruited. A control group included five healthy women aged 20 to 35 years with a BMI <25 kg/m². Markers of adiposity were assessed, including BMI, percentage of fat mass (PFM, %), and waist-to-height ratio (WHR). All participants underwent a 7-day continuous glucose monitoring (CGM). Blood samples were collected to assess leukocyte count (10³/μL), neutrophils (%), lymphocytes (%), monocytes (%), eosinophils (%), fasting plasma glucose, insulin, and HOMA-IR (>2.5). Participants were instructed to maintain their usual diet and physical activity. Student’s t-test was used to compare group means.

Results: The PCOS group had a BMI range of 18.5–29.9 kg/m², which was significantly higher than the control group (p<0.04). There was a trend toward higher WHR (p<0.07) and PFM (p<0.09) in the PCOS group compared to controls. No differences were observed in fasting plasma glucose between groups. Only 20% (n=2) of the PCOS participants had insulin resistance; however, there was a trend toward higher plasma insulin levels (p<0.08) and HOMA-IR values (p<0.07) in the PCOS group. Average interstitial glucose levels were 80.4 ± 11.0 mg/dL for the PCOS group and 91.2 ± 2.6 mg/dL for the control group, with a trend toward lower values in the PCOS group (p=0.053). No participants showed leukocytosis; however, leukocyte counts (p<0.02), particularly monocytes (p<0.002), were significantly higher in the PCOS group.

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Conclusion: Women with PCOS presented higher levels of adiposity, inflammatory markers, and indicators of carbohydrate metabolism dysregulation. Elevated leukocyte and monocyte counts may serve as early markers of metabolic disturbance before the onset of hyperinsulinemia in PCOS.

Disclosure of Interest: None declared