PD580 - PERSISTENT REDUCTION OF N-3 POLYUNSATURATED FATTY ACIDS POST-BARIATRIC SURGERY: A POTENTIAL NEED FOR NUTRITIONAL REASSESSMENT

PD580

PERSISTENT REDUCTION OF N-3 POLYUNSATURATED FATTY ACIDS POST-BARIATRIC SURGERY: A POTENTIAL NEED FOR NUTRITIONAL REASSESSMENT

O. Lange-Andrzejewska^1,*, A. Janczy², M. Proczko-Stepaniak³, M. Szymanski³, M. Wilczynski³, A. Mika⁴, A. Budny ⁵

¹Department of Environmental Analysis, University of Gdansk, ²Division of Food Commodity Science, ³Department of Surgical Oncology, Transplant Surgery and General Surgery, ⁴Department of Pharmaceutical Biochemistry, ⁵Hypertension & Diabetology, Medical University of Gdansk, Gdansk, Poland

Rationale: Bariatric surgery (BS) effectively treats severe obesity and improves metabolism beyond weight loss [1], but its long-term effects on circulating fatty acid (FA) profiles across procedures are not fully understood. This study examined time- and procedure-specific changes in FA profiles after laparoscopic sleeve gastrectomy (LSG) and one-anastomosis gastric bypass (OAGB).

Methods: Circulating FAs were longitudinally measured in women undergoing LSG or OAGB at baseline and follow-up using GC-MS. Two-way ANOVA assessed the effects of procedure, time, and their interaction.

Results: BS was associated with pronounced time-dependent remodelling of FA profiles. Several polyunsaturated FAs (PUFAs), including ALA, EPA, and DGLA, showed a consistent postoperative decline independent of surgical procedure. Significant operation × time interactions were identified, including DHA, ARA, and branched-chain fatty acids (BCFA), indicating divergent postoperative trajectories between surgical procedures. 

Conclusion: Bariatric surgery induces significant time-dependent changes in circulating fatty acid profiles, and the type of surgical procedure influences the temporal regulation of specific bioactive lipids. Although LSG and OAGB show similar clinical efficacy, distinct metabolic adaptations are observed in fatty acid metabolism. The persistent postoperative reduction in several n-3 polyunsaturated fatty acids suggests a potential need to reassess nutritional strategies after bariatric surgery.

References: [1] Mika A, Janczy A, Waleron K, Szymanski M, Kaska L, Sledzinski T. The impact of the interplay of the intestinal microbiome and diet on the metabolomic and health outcomes of bariatric surgery. Obes Rev. 2022;23(8):e13455. doi:10.1111/obr.13455

Disclosure of Interest: None declared