LB092 - A PRELIMINARY ANALYSIS OF A RETROSPECTIVE OBSERVATIONAL STUDY WITH A DIABETES-SPECIFIC FORMULA IN TYPE-2 DIABETES MELLITUS PATIENTS WITH DISEASE-RELATED MALNUTRITION

LB092

A PRELIMINARY ANALYSIS OF A RETROSPECTIVE OBSERVATIONAL STUDY WITH A DIABETES-SPECIFIC FORMULA IN TYPE-2 DIABETES MELLITUS PATIENTS WITH DISEASE-RELATED MALNUTRITION

M. Ferrer¹, P. Suarez², B. Gonzalez Aguilera³, N. Cruz⁴, M. Blanco⁵, M. Layola Brias^5,*

¹Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, ²Unidad de Nutrición Clínica y Dietética, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, ³Endocrinología y Nutrición, Hospital Universitario Virgen de la Macarena, Sevilla, ⁴Endocrinología y Nutrición, Complejo Hospitalario Universitario Insular, Las Palmas de Gran Canaria, ⁵Departamento Médico, Nestlé Health Science Spain, Barcelona, Spain

 

Rationale: Disease-related malnutrition (DRM) in type 2 diabetes mellitus (T2DM) causes unintended weight loss and risk of sarcopenia, potentially affecting patients’ functional status and which may lead to an increased use of healthcare resources, which highlights the importance of nutritional interventions. This study aims to assess the impact of a diabetes-specific formula (DSF) [RSC Diabet plus®], on glycemic control, the nutritional and functional status, and healthcare resource utilization in adults with T2DM and DRM.

 

 

Methods: A multicenter, one-arm retrospective observational study (NCT06866366) was conducted including data from adult malnourished (GLIM criteria) patients with T2DM who received a DSF [RSC Diabet plus®]. Nutritional and functional status (handgrip strength) and HbA1c were assessed prior DSF prescription and at 24 weeks of follow-up. Data regarding sociodemographic, comorbidities and healthcare resource use, including emergency room (ER) admissions and hospitalizations were also collected during the follow-up. A preliminary analysis was performed (STATA v14) to show changes between visits (p value<0.05 was considered significant).

Results: The preliminary analysis was conducted on 55 patients, (65.4% male, mean age 70.6±10.4 years) being 78.2% multimorbid, mainly with cardiovascular disease, followed by gastrointestinal and endocrine conditions. At baseline, 66.0% of patients had moderate and 30.2% had severe malnutrition (GLIM criteria). By week 24, 74.5% significantly improved their nutritional status (p<0.001), downgrading from severe to moderate, or from moderate to no malnutrition. Baseline mean handgrip strength was 23.9±9.6 kg; after 24 weeks, it increased significantly by 2.7±2.7 kg (p<0.001). Baseline mean HbA1c was 7.2±1.3%, after 24 weeks (6.9±1.04%), 58.5% of patients showed improvements (p=0.051). During the follow-up, only 12.7% of patients were admitted to ER or the hospital for any cause.

 

 

 

 

Conclusion: Our findings show significant impact on nutritional and functional status using a DSF, with close to 60% of patients improving their metabolic control. Considering this is an elder, multimorbid, diabetic population, a low rate of ER and hospital admissions were observed. This highlights the significance of receiving a specific nutritional intervention for optimal health outcomes and prevention. 

 

 

This research was funded by Nestlé Health Science Spain.

References: - G. Olveira1, M.ª J. Tapia1 y N. Colomo1, Costes frente a beneficios de los suplementos nutricionales orales. Nutr.Hosp, 2009. 23

- T.F. Galeano-Fernández, J.C.-G., A.S. Vidal-Ríos, G.M. García-García, C. García-Carrasco, F.J. Monreal-Periañez, P. González-González, S. Córdoba-Bueno, A. Pijierro-Amador, J.C. Arévalo-Lorido, Impacto de la diabetes, la desnutrición y la sarcopenia en el pronóstico de los pacientes hospitalizados en Medicina Interna. Rev Clin Esp, 2023. 223: p. 523-531.

Disclosure of Interest: M. Ferrer: None declared, P. Suarez Paid Instructor at: The author has been compensated for speaking engagements related to this subject, B. Gonzalez Aguilera: None declared, N. Cruz: None declared, M. Blanco Other: Works at Nestlé Health Science Spain, M. Layola Brias Other: Works at Nestlé Health Science Spain