PP339 - EFFECT OF PARTIALLY HYDROLYZED GUAR GUM- CONTAINING ENTERAL NUTRITION FORMULA ON FEEDING TOLERANCE IN PATIENTS WITH MULTIPLE TRAUMA: AN EXPLORATORY CLINICAL STUDY

PP339

EFFECT OF PARTIALLY HYDROLYZED GUAR GUM- CONTAINING ENTERAL NUTRITION FORMULA ON FEEDING TOLERANCE IN PATIENTS WITH MULTIPLE TRAUMA: AN EXPLORATORY CLINICAL STUDY

Y. Fang^1,2,*, C. Wang³, X. Chen³, J. Sun⁴, D. Tan⁵

¹Yangzhou University, Yangzhou University, Yangzhou, Jiangsu province, China 225001, Yangzhou, Jiangsu province, ²Department of Emergency Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu province, China 225001, Yangzhou, Jiangsu province, ³Department of Emergency Medicine, ⁴Department of Pharmacy, ⁵ Department of Emergency Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu province, China 225001, Yangzhou, Jiangsu province, China

Rationale: Multiple injuries often lead to inadequate intake and feeding intolerance (FI), increasing risks of infection and sepsis. This study evaluated whether partially hydrolyzed guar gum (PHGG)-containing enteral nutrition (EN) improves FI, reduces post-traumatic sepsis, and modulates gut microbiota in these patients.

Methods: In this exploratory randomized clinical study (ChiCTR2200066926), 79 ICU patients requiring EN were analyzed (PHGG group, n=40; control group, n=39). Patients received PHGG-containing or standard EN via nasogastric feeding for 7 days. EN started within 3–5 days post-admission at 25–50 mL/h, targeting 25 kcal/kg/day and 1.5 g protein/kg/day. The primary outcome was the day-7 EN tolerance score. Secondary outcomes included sepsis incidence, Acute Gastrointestinal Injury (AGI) grade, nutritional status, stool microbiota changes, ICU stay, ventilation duration, and 28-day survival.

Results: The PHGG group showed a significantly lower enteral nutrition tolerance score than the control group on day 7 (3 [2-4] vs 4 [2-4], p=0.018). The proportion of patients with AGI grade II was lower in the PHGG group (12.5% vs 30.8%, p=0.048). Sepsis incidence during ICU stay was significantly reduced with PHGG (17.5% vs. 38.5%, p=0.038). Gut microbiota analysis showed significant differences in beta diversity. PHGG enrichment was observed for Bacteroidota, Parabacteroides, and Bacteroides, while abundances of Proteobacteria, Fusobacterium, Sutterella, and Pseudomonas were higher in controls. No significant differences were found in 28-day mortality or ICU stay (p>0.05).

Conclusion: PHGG-containing EN improves feeding tolerance, reduces post-traumatic sepsis incidence, and optimizes intestinal microecology in patients with multiple injuries, demonstrating significant clinical application value.

Disclosure of Interest: Y. Fang Other: No Conflict of Interest, C. Wang Other: No Conflict of Interest, X. Chen Other: No Conflict of Interest, J. Sun Other: No Conflict of Interest, D. Tan Other: No Conflict of Interest