P373 - SARC-F SCORE AS A PREDICTOR OF ONCOLOGIC OUTCOMES AFTER COLORECTAL CANCER SURGERY

P373

SARC-F SCORE AS A PREDICTOR OF ONCOLOGIC OUTCOMES AFTER COLORECTAL CANCER SURGERY

S. Bae^1,*, W. K. Jeong¹, S. K. Baek¹

¹Keimyung University, Daegu, Korea, Republic Of

Rationale: The dietary inflammatory index (DII) helps quantify the inflammatory potential of diet. Despite numerous studies on the correlation between DII and colorectal cancer (CRC) risk, its relationship with clinical or oncologic outcomes in CRC remains unexplored. This study examined the impact of preoperative inflammatory potential of individual dietary patterns on clinical and oncologic outcomes following CRC surgery.

Methods: This study included 126 patients who underwent surgical treatment for CRC and completed a food frequency questionnaire (FFQ) preoperatively between January 2018 and June 2020. The DII was calculated by analyzing responses to a 109-item semi-quantitative FFQ.

Results: An optimal DII cut-off value of 0.90182 was used to categorize patients into the high-DII (n=28) and low-DII (n=98) groups. The high-DII group exhibited an older age (71.5 vs. 67.0, p=0.020) and a significantly higher complication risk within 30 days postoperatively than the low-DII group (57.1% vs. 35.7%, p=0.042). No significant difference was observed between the two groups in other perioperative clinical outcomes. The 5-year overall survival (OS) rates were 90.4% and 41.3% in the low-DII and high-DII groups, respectively, in univariate survival analysis (p=0.044). However, no statistical difference was observed in the disease-free survival (DFS) rate. In the multivariate survival analysis, low-DII (hazard ratio [HR]: 0.118; 95% confidence interval [CI]: 0.023–0.613, p=0.011) and M1 stage (HR: 10.910; 95% CI: 1.491–79.847, p=0.019) were identified as independent prognostic factors for OS, while perineural invasion (HR: 3.495; 95% CI: 1.059–11.533, p=0.040) served as an independent prognostic factor for DFS.

Conclusion: A preoperative high DII score was associated with an increased incidence of postoperative complications and served as an independent prognostic factor for OS.

Disclosure of Interest: None declared