PT19 - RISKS OF DYSPHAGIA WITH ANTIPSYCHOTIC MEDICATION IN ACUTE HEART FAILURE: IMPLICATIONS FOR NUTRITIONAL AND FUNCTIONAL CARE

PT19

RISKS OF DYSPHAGIA WITH ANTIPSYCHOTIC MEDICATION IN ACUTE HEART FAILURE: IMPLICATIONS FOR NUTRITIONAL AND FUNCTIONAL CARE

H. Matsuo^1,*

¹Kagoshima Medical Association Hospital, Kagoshima, Japan

Rationale: While antipsychotic drugs are known to induce dysphagia, their impact on patients with acute heart failure (AHF) remains largely unexplored. This study investigates the critical association between antipsychotic use and both swallowing and physical function in AHF patients.

Methods: A prospective cohort study was conducted on hospitalized patients with AHF. We examined the relationship between the use of antipsychotic drugs during hospitalization and swallowing and physical function at discharge. Antipsychotic drug use was defined as the regular administration of oral medication. The primary outcome was dysphagia, evaluated using the Food Intake Level Scale (FILS), with secondary outcomes including physical function (Barthel Index) and dysphagia incidence. Analyses adjusted for confounders, including age, gender, comorbidities, cognitive function, physical function, nutritional status, medication number, and antipsychotic use (P<0.05 significance).

Results: A total of 325 patients (mean age 81.5 years; 173 women) were included in the analysis, with 34 patients (10.5%) in the antipsychotic drug use group and 291 (89.5%) in the non-use group. The antipsychotic drug group was older and had lower muscle mass and strength, poorer cognitive function, worse nutritional status, lower nutritional intake, a higher total number of medications, and poorer swallowing and physical function. Multivariate analysis showed that antipsychotic drug use during hospitalization was significantly associated with FILS at discharge (OR = 7.724; 95% CI, 2.585-23.081, p < 0.001) and the incidence of dysphagia (HR = 1.635, 95% CI, 1.002-2.669, p = 0.049), but not with BI at discharge (β = 0.015; p = 0.658).

Conclusion: Antipsychotic use during hospitalization was significantly associated with impaired swallowing function and markedly increased risk of dysphagia in AHF patients.

Disclosure of Interest: None declared