Sep 13, 2025
1:00 PM2:00 PM
Poster Session
P062 - MINERAL AND METABOLIC DISORDERS IN SURGICALLY CRITICALLY ILL PATIENTS PRIOR TO RECEIVING TOTAL PARENTERAL NUTRITION
P062
MINERAL AND METABOLIC DISORDERS IN SURGICALLY CRITICALLY ILL PATIENTS PRIOR TO RECEIVING TOTAL PARENTERAL NUTRITION
J. A. Heiderich Domingues1,*, F. D. O. Souza1, R. J. N. Nogueira1, T. D. R. Hortencio1
1Medicine, São Leopoldo Mandic, Campinas, Brazil
Rationale: Metabolic disorders are common complications in surgically critically ill patients receiving total parenteral nutrition (TPN), potentially impacting clinical outcomes and recovery. This study aimed to investigate the prevalence of hypomagnesemia, hypophosphatemia, and hypokalemia, as well as the patterns of metabolic disorders in surgical critically ill patients prior to receiving exclusive TPN.
Methods: This is a historical cohort study analyzing prospectively collected data from 945 adult patients receiving TPN over a three-year period at a referral center. Serum levels were obtained
up to 48 hours before starting PN infusion. Laboratory monitoring included lipids (triglycerides, total cholesterol, HDL), liver parameters (ALT, GGT), albumin, and C-reactive protein (CRP). Mineral levels (phosphorus, potassium, magnesium) were monitored and corrected, if necessary, before starting PN treatment.
Results: Of 566 patients, 65% were male with a mean age of 54.4 ± 16.3 years. Metabolic disorders were highly prevalent before starting PN: hypomagnesemia was observed in 14.8% of patients (14.3% severe cases), hypophosphatemia in 9.9% (3.5% severe), and hypokalemia in 5.8% (1.1% severe). Regarding inflammatory and metabolic markers, 44.7% presented low albumin (<3.5 g/dL), 23.3% had low HDL (<40 mg/dL), 15.4% showed elevated triglycerides, and 17.8% had high CRP. Liver enzyme alterations were present, with elevated GGT in 29.7%, AST in 15.0%, and ALT in 9.4% of patients.
Conclusion: This study highlights the high prevalence of mineral and metabolic disorders, in surgically critically ill patients before starting TPN.
Disclosure of Interest: None declared