P756 - GLYCAEMIC CONTROL IN PERITONEAL DIALYSIS PATIENTS

P756

GLYCAEMIC CONTROL IN PERITONEAL DIALYSIS PATIENTS

T. Simčič^1,*, A. Poročnik¹, B. Knap^2,3

¹Department for food science, Biotechnical Faculty, ²Department of Nephrology, University Clinical Centre Ljubljana, ³Medical faculty, Universtity of Ljubljana, Ljubljana, Slovenia

Rationale: Peritoneal dialysis (PD) patients face unique metabolic challenges, including glucose absorption from dialysate and altered dietary needs. Our study compares glycaemic control and dietary intake aspects between PD patients and healthy individuals.

Methods: This cross-sectional study of 19 male patients and 10 male controls examined the relationship between glycaemic control and dietary intake, including dialysate glucose. Interstitial glucose levels were monitored for 10 days using the Dexcom G7 continuous glucose monitoring system. Dietary intake was assessed using 24-hour recall.

Results: PD patients exhibited significantly higher mean glucose levels than controls (6,66±0,83 to 5,91±0,48 mmol/L, p=0,01). Time in range (TIR) was slightly lower in patients (94,58±7,47% to 96,90±2,13%), though this difference was not significant (p=0,87). Patients had a higher glucose management indicator (GMI) (6,22±0,36% to 5,86±0,22%, p=0,008) and a higher coefficient of variation (CV) (19,85±5,97% to 17,28±2,42%), but the difference was not significant (p=0,31). Glucose absorbed from dialysate contributed to a substantial proportion of daily energy intake in patients. A statistically significant inverse correlation was observed between the percentage of energy from dialysate glucose and total dietary energy intake (p=0.01). However, the proportion of energy from dialysate glucose was not significantly associated with markers of glycaemic control (p>0,05), such as mean glucose, TIR, GMI or CV. Sugar intake from food and dialysate accounted for a significantly higher proportion of daily energy intake in patients than in controls (31,08±8,96% to 13,50±6,39%, p=0,04).

Conclusion: PD patients exhibit significantly poorer glycaemic control compared to controls, evidenced by higher mean glucose levels and elevated GMI. While dialysate glucose unavoidably affects energy balance, nutritional strategies may complement glucose-lowering interventions in PD patients.

Disclosure of Interest: None declared