P1069 - LOW PREOPERATIVE PREALBUMIN INCREASES NON-GASTRIC CANCER MORTALITY INDEPENDENT OF PSTAGE IN PATIENTS WITH GASTRIC CANCER AFTER GASTRECTOMY: A RETROSPECTIVE COHORT STUDY

P1069

LOW PREOPERATIVE PREALBUMIN INCREASES NON-GASTRIC CANCER MORTALITY INDEPENDENT OF PSTAGE IN PATIENTS WITH GASTRIC CANCER AFTER GASTRECTOMY: A RETROSPECTIVE COHORT STUDY

R. Matsui^1,*, K. Ishibayashi¹, K. Doden¹, K. Hayashi¹, S. Hayashi¹, H. Saito¹, T. Tsuji¹, D. Yamamoto¹, H. Moriyama¹, J. Kinoshita¹, N. Inaki¹

¹Department of Gastrointestinal Surgery, Kanazawa University, Kanazawa, Japan

Rationale: The prognostic impact of the preoperative prealbumin levels divided by pStage in patients with gastric cancer has not yet been studied. The purpose of this research was to examine relationship with preoperative prealbumin levels and long-term outcomes in patients with early or advanced gastric cancer after undergoing gastrectomy.

Methods: This study involved patients who had radical gastrectomy for primary pStage I–III gastric cancer, with preoperative prealbumin levels measured from May 2006 to March 2017. Patients were categorized into three groups based on their preoperative prealbumin levels: high (≥22 mg/dL), moderate (15–22 mg/dL), and low (<15 mg/dL). The primary outcome was overall survival (OS), defined as the duration from surgery to death.

Results: Of the 4,732 patients, 3,050 (64.5%) were pStage I and 1,682 (35.5%) were pStage II or III. Of the 3,050 patients with pStage I, 2,488 (81.6%) were classified as high, 511 (16.8%) as moderate, and 51 (1.7%) as low. Of the 1,682 patients with pStage II-III, 1,161 (69.0%) were classified as high, 414 (24.6%) as moderate, and 107 (6.4%) as low. A comparison of OS revealed that lower prealbumin levels were associated with a worse prognosis (P<0.001). Multivariate analysis indicated that prealbumin levels of 15–22 mg/dL and <15 mg/dL were independent poor prognostic factors for OS, regardless of pStage. When stratified by cause of death, prealbumin levels were associated with other cause survival but not with cancer-specific survival.

Conclusion: Preoperative prealbumin levels were correlated with OS, especially other cause survival, in patients with gastric cancer after gastrectomy.

Disclosure of Interest: None declared