PT52 - TRIGLYCERIDE-GLUCOSE (TYG) INDEX AS A PREDICTOR OF POSTOPERATIVE COMPLICATION IN MAJOR ABDOMINAL SURGERY

PT52

TRIGLYCERIDE-GLUCOSE (TYG) INDEX AS A PREDICTOR OF POSTOPERATIVE COMPLICATION IN MAJOR ABDOMINAL SURGERY

C. Tedjaatmadja^1,*, Y. Wulandari¹, A. S. Putranto²

¹Department of Nutrition , ²Department of Digestive Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Rationale: Insulin resistance plays an important role in the occurrence of postoperative complication in patients undergoing major abdominal surgery. The Triglyceride-Glucose (TyG) index is a novel, simple, and cost-effective marker for assessing insulin resistance. There is limited evidence regarding relationship between TyG index as a predictor of postoperative complication in major abdominal surgery.

Methods: This prospective cohort study included 124 adult patients in Dr. Cipto Mangunkusumo National General Hospital. Triglyceride and blood glucose levels were measured to calculate the TyG Index using the formula Ln[triglyceride (mg/dL) x blood glucose (mg/dL)]/2. Blood triglyceride and glucose levels were taken on the day of surgery after the patient has undergone a minimum of 3 hours of fasting, either orally or parenterally Postoperative complications were defined as patients classified in Clavien-Dindo grading systems (grade II-V).

Results: The mean TyG index in this study was 4.65 ± 0.28, with median of triglyceride and blood glucose were 119 mg/dL and 86 mg/dL, respectively. The incidence of postoperative complications was 46.8%. Bivariate analysis showed a significant association between preoperative TyG index and postoperative complications of major abdominal surgery patients. (RR=1.583; p=0.016; 95% CI=1.100-2.277). ROC analysis was performed to define the cut-off point of the TyG index. The area under the curve was 0,622 (p=0.19; 95% CI=0.524-0.721), with cut-off point for TyG index was 4.70 (sensitivity: 47%; specificity: 75.8%).

Conclusion: The preoperative TyG index is a valuable predictive marker for postoperative complications in patients undergoing major abdominal surgery. A TyG index exceeding 4.70 is associated with an increased risk of postoperative complications in major abdominal surgery.

Disclosure of Interest: None declared