PP450 - BLUNTED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) RESPONSE TO WALKING EXERCISE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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PP450

BLUNTED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) RESPONSE TO WALKING EXERCISE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

M. C. Kang1,*, N. E. Deutz1,2, C. L. Cruthirds1, C. N. Perez1, M. P. Engelen1,2

1Center for Translational Research in Aging and Longevity, Texas A&M University, 2Primary Care & Rural Medicine, Texas A&M University, College Station, United States

 

Rationale: Cognitive deficits have been observed in patients with Chronic Obstructive Pulmonary Disease (COPD), and exercise training improves cognitive function. Myokines, released by skeletal muscle, mediate neuroprotective effects of exercise. We investigated whether the plasma myokine response to exercise is influenced by exercise intensity and altered in COPD.

Methods: In 16 (9f/7m) patients with stable COPD (GOLD II-IV) and 12 (7f/5m) healthy controls, body composition was assessed by DXA. The COPD group completed a 20 min walking session on a treadmill at their max speed. Healthy controls completed two 20 min walking tests on separate days: 1) speed matched with COPD counterparts, 2) own max speed. Plasma myokine concentrations before and immediately after the walking test: Human Myokine Magnetic Bead Panel (Luminex). Stat: GLMM to test the effect of COPD, exercise, and walking speed. Data: adjusted for sex and distance walked.

Results: Lean soft tissue and fat mass were comparable between the groups. In healthy controls, the response to matched and max speed exercise was comparable for all myokines (all P>0.22). We observed a comparable exercise-induced increase in CX3CL1, BDNF, EPO, osteonectin, LIF, IL-15, myostatin, FABP-3, FSTL-1, oncostatin-M, FGF-21, and osteocrin in COPD and healthy controls (speed matched). However, COPD patients showed a blunted BDNF response to exercise compared with healthy individuals (228 [144, 312] vs 61 [39, 84], P<0.001), while osteocrin response was greater in COPD (P<0.001).

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Conclusion: A 20-min walking bout increased many plasma myokines. Whether the blunted BDNF response to acute exercise might partially explain the observed cognitive decline in COPD patients needs further investigation. The comparable myokine response between low and high speed in healthy individuals might indicate a ceiling in exercise-induced increase in BDNF.

Disclosure of Interest: None declared