PP037
ASSOCIATION OF C-REACTIVE PROTEIN-TRIGLYCERIDE-GLUCOSE INDEX WITH INCIDENT FRAILTY RISK AND JOINT STRATIFICATION BY HANDGRIP STRENGTH: A METABOLIC–FUNCTIONAL DUAL-DIMENSIONAL ASSESSMENT IN MIDDLE-AGED AND OLDER ADULTS
C. Chen1,*, X. Shen1, W. Sun1, Y. Hu1
1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Rationale: Frailty is a key pre-disability state in older adults, yet conventional assessment tools are subjective and impractical for large community screening. The C-reactive protein-triglyceride-glucose index (CTI), a routine biochemistry–based metric, may enable objective frailty risk stratification.
Methods: This prospective cohort used 2011–2018 China Health and Retirement Longitudinal Study (CHARLS) data, enrolling 7,358 non-frail participants aged ≥45 years (baseline Frailty Index, FI<0.25) with median 5-year follow-up. CTI was calculated and divided into quartiles; low grip strength was defined by AWGS 2025. The primary outcome was incident frailty (FI≥0.25). Associations were examined using Cox regression, restricted cubic spline (RCS), subgroup and joint stratification analyses.
Results: During follow-up, 2,090 (28.4%) participants developed frailty. In fully adjusted models, each 1-unit CTI increase was associated with 21% higher frailty risk (HR=1.21, 95%CI:1.12–1.31, P<0.001); the highest CTI quartile (Q4) conferred 32% higher risk versus Q1 (HR=1.32, 95%CI:1.16–1.50, P for trend<0.001). RCS confirmed a linear dose–response relationship (P for nonlinearity=0.373). The association was stronger in adults <60 years and most prominent in underweight Q4 participants (HR=1.82, 95%CI:1.17–2.83, P=0.008). Participants with high CTI plus low grip strength had the highest frailty risk (HR=2.43, 95%CI:1.92–3.08, P<0.001).
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Conclusion: Elevated CTI independently predicts incident frailty with a linear dose–response pattern. Combined CTI and grip strength assessment improves identification of high-risk community individuals, supporting targeted frailty prevention.
Disclosure of Interest: None declared