P1042 - EFFECT OF WHOLE-COURSE NUTRITIONAL MANAGEMENT ON SKELETAL MUSCLE MASS IN PATIENTS WITH GASTRIC CANCER UNDERGOING NEOADJUVANT TREATMENT

P1042

EFFECT OF WHOLE-COURSE NUTRITIONAL MANAGEMENT ON SKELETAL MUSCLE MASS IN PATIENTS WITH GASTRIC CANCER UNDERGOING NEOADJUVANT TREATMENT

C. Liu^1,*, J. Yu¹

¹Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Rationale: To investigate the effect of whole-course nutritional management on postoperative skeletal muscle mass, incidence of complications, readmission rate and overall survival in patients with gastric cancer undergoing neoadjuvant treatment.

Methods: Patients with gastric cancer who underwent radical gastrectomy after neoadjuvant treatment from January 2016 to December 2020 were retrospectively analyzed. The patients were divided into whole-course nutritional management group and control group. Clinical data including demographic information, duration of neoadjuvant chemotherapy regimen, radiotherapy or not, nutritional assessment, nutritional intervention, surgery, pathology, and adjuvant therapy were collected. The primary outcome was muscle mass measured by CT at 6 months after surgery compared with that before neoadjuvant therapy, which was the cross-sectional area of the third lumbar spine measured by ImageJ software.

Results: A total of 182 patients with neoadjuvant gastric cancer were enrolled, including 135 males and 47 females, with an average age of 60.14±10.3 years. After propensity score matching, 110 patients in the whole-course nutritional management group and 57 patients in the control group were analyzed. The change in skeletal muscle area was significantly different between the two groups (P= 0.045), but there were no significant differences between the two groups in the incidence of in-hospital complications, 90-day readmission rate, overall survival and disease-free survival.

Conclusion: For patients with neoadjuvant gastric cancer, whole-course nutritional management can significantly improve the loss of skeletal muscle mass, but it does not significantly reduce the incidence of hospital complications and readmission rates, nor prolong the survival time.

Disclosure of Interest: None declared