PD696 - PROGNOSTIC IMPACT OF GLIM-DEFINED MALNUTRITION AND PHASE ANGLE IN PATIENTS WITH DIGESTIVE TUMORS

PD696

PROGNOSTIC IMPACT OF GLIM-DEFINED MALNUTRITION AND PHASE ANGLE IN PATIENTS WITH DIGESTIVE TUMORS

M. GONZALEZ PACHECO^1,*, C. López-Pereira¹, A. Gramage-Viñets¹, A. Lara-Barea¹, F. J. Vílchez-López¹

¹Department of Endocrinology and Nutrition, Puerta del Mar University Hospital, Cádiz, Spain

Rationale: Disease-related malnutrition is frequent in patients with digestive tumors and is associated with poorer prognosis. We evaluated the association between GLIM-defined malnutrition, phase angle, and overall survival.

Methods: Retrospective longitudinal observational study including 131 adult patients with digestive neoplasms. Nutritional status was established according to GLIM criteria. Bioelectrical impedance analysis was performed with phase angle determination. GLIM categories were compared using ANOVA with Games-Howell post hoc analysis. The association between phase angle and nutritional severity was analyzed using multivariable logistic regression adjusted for age and sex. Mortality was assessed using Cox regression adjusted for age, sex, and phase angle.

Results: Significant differences were observed across GLIM categories in body cell mass (24.9, 21.4, and 20.8 kg; p=0.032), appendicular skeletal muscle mass (20.8, 17.7, and 17.6 kg; p=0.028), fat mass index (7.73, 6.45, and 4.38; p<0.001), and fat-free mass index (19.3, 18.1, and 17.0; p<0.001). Lower phase angle was associated with greater nutritional severity between moderate and severe malnutrition (OR 2.51; 95% CI 1.26–4.99; p=0.009), after adjustment for age and sex. A phase angle cut-off of 3.8° was identified, with a median survival of 38.5 months for values ≥3.8° versus 10.5 months for values <3.8°. In the Cox model adjusted for age, sex, and phase angle, malnutrition was independently associated with higher mortality (HR 4.35; 95% CI 1.04–16.67; p=0.044), whereas phase angle showed a protective association (HR 0.57; 95% CI 0.34–0.97; p=0.039).

Conclusion: GLIM-defined malnutrition is independently associated with poorer overall survival in patients with digestive tumors. Phase angle provides additional prognostic information and may improve risk stratification.

Disclosure of Interest: None declared