PD096 - PHASE ANGLE AND PULMONARY FUNCTION IN PULMONARY HYPERTENSION

PD096

PHASE ANGLE AND PULMONARY FUNCTION IN PULMONARY HYPERTENSION

V. Maldonado-Vargas^1,2, N. López-Hernández², A. Orea-Tejeda², D. González-Islas², S. Alday-Ramirez², G. Cruz-Gijón², G. Rentería-Serralde², G. Benítez-Moya^2,*, E. Vargas-Corona², J. De la Borda-Paredes², L. Ramírez-Morales², D. Bonilla-Cuatepotzo², K. García-Díaz², R. Sánchez-Santillán², B. Valderrábano-Salas², J. Ruan-Díaz²

¹FACULTAD DE ESTUDIOS SUPERIORES ZARAGOZA, UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, ²Unidad Clínica de Investigación Cardiopulmonar y Metabólica. Servicio de Cardiología, INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS "ISMAEL COSÍO VILLEGAS", MÉXICO, Mexico

Rationale: Pulmonary hypertension (PH) is characterized by a mean pulmonary arterial pressure (mPAP) greater than 20 mmHg(1). In cases of chronic diseases, PhA is usually low and is associated with lower exercise tolerance, quality of life, and prognosis(2,3). Thus, our aim is to explore the association between PhA and pulmonary function in patients with PH.

Methods: This cross-sectional study included patients older than 18 years with a confirmed diagnosis of PH (mPAP >20 mmHg), measured by heart catheterization. Patients with hospitalization within the three months previous were excluded. Body composition was measured by bioelectrical impedance analysis, and low-PhA was defined as <5°. Respiratory function was assessed by spirometry. Group differences were analysed using the X² and t-student test for the categorical and numerical variables, respectively.

Results: 60 patients were evaluated; 55% women, with a mean age 51.65±15.41 and a mPAP of 37.91±13.71. The prevalence of diabetes was 26%, hypertension 33.33%, and ILD 45.83%. The low-PhA group was older (59.83±15.41 vs 48.14±14.40), had higher BNP (518.13±498.59 vs 171.19±278.56), and lower hemoglobin (13.45±2.19 vs 15.36±2.84) compared with the high-PhA group. For PF, the high-PhA group showed greater FEV1 (1.87±0.89 vs 1.26±0.72, p 0.044) than the low-PhA group.

Image:

Conclusion: In patients with PH, low-PhA is associated with worse pulmonary function.

References:         1. Humbert M, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022 Oct 11;43(38):3618–731.

        2. Norman K, et al. Bioelectrical phase angle and impedance vector analysis – Clinical relevance and applicability of impedance parameters. Clinical Nutrition. 2012 Dec;31(6):854–61.

        3. Kobayashi T, et al. Phase angle as an indicator of physical activity in patients with stable chronic obstructive pulmonary disease. Nutrition. 2024 Apr;120:112330.

Disclosure of Interest: None declared