LB022 - DIFFERENTIAL ASSOCIATION OF PHASE ANGLE WITH ACYLCARNITINE METABOLITES AND MUSCLE STRENGTH IN WOMEN WITH AND WITHOUT DYSMENORRHEA

LB022

DIFFERENTIAL ASSOCIATION OF PHASE ANGLE WITH ACYLCARNITINE METABOLITES AND MUSCLE STRENGTH IN WOMEN WITH AND WITHOUT DYSMENORRHEA

S. Khatun^1,*, A. Uchizawa^2,3,4,5, E. Kondo⁶, K. Yajima⁷, D. Hoshi⁸, Y. Tanaka⁹, N. Mukai², K. Watanabe², K. Tanaka², H. Sagayama^2,3

¹Graduate School of Comprehensive Human Sciences, ²Institute of Health and Sport Sciences, ³Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba, Ibaraki, ⁴Japan Society for the Promotion of Science, ⁵Department of Sports Sciences and Research, Japan Institute of Sports Sciences, Tokyo, ⁶Department of Sport Sciences, Osaka University of Health and Sport Sciences, Osaka, ⁷Faculty of Pharmaceutical Sciences, Josai University, Saitama, ⁸Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki, ⁹Department of Sport Sciences, Japan Institute of Sports Sciences, Tokyo, Japan

Rationale: Dysmenorrhea, painful menstruation caused by inflammatory hormones such as prostaglandins (PGs) and cytokines, may alter body composition, muscle strength, and metabolic function. This study aimed to examine the associations between the phase angle (PhA), body composition variables, muscle strength, and urine metabolites in women with and without dysmenorrhea.

Methods: Fifteen non-dysmenorrhea (27.6 ±8.6 yr) and 19 dysmenorrhea (30.5 ±9.7 yr) participants underwent bioelectrical impedance analysis, computed tomography, dynamometry, and liquid chromatography. We measured PhA, visceral fat, subcutaneous fat, hand grip strength, leg strength, and 41 urine metabolites (glycolytic intermediates, amino acids, acylcarnitines (AC), and bile acids). Principal component analysis identified the most influential metabolites (absolute loading ≥0.25 on PC1 and PC2). Spearman heatmap and age-adjusted partial correlation analysis were used to assess the relationships between selected metabolites, body composition variables, and muscle strength.

Results: In the non-dysmenorrhea group, PhA positively correlated with BMI (R = 0.709), leg strength (R = 0.732), total AC (ρ = 0.544), and C2-AC (ρ = 0.569). In the dysmenorrhea group, the total AC was positively correlated with visceral fat (ρ = 0.456) (p < 0.05).

Conclusion: PhA reflects cellular health, whereas AC supports mitochondrial fatty acid oxidation. In non-dysmenorrhea, the positive association between PhA, BMI, leg strength, and AC indicated robust muscle quality and metabolic efficiency. Conversely, inflammatory mediators in dysmenorrhea impair mitochondrial fatty acid oxidation, leading to oxidative stress and elevated AC levels. The positive association between visceral fat and AC in dysmenorrhea may reflect metabolic alterations and may promote visceral fat accumulation.

Disclosure of Interest: None declared