PD679 - PROGNOSTIC VALUE OF RECTUS FEMORIS ULTRASOUND IN LUNG CANCER: SEX DIFFERENCES AND ASSOCIATION WITH MORTALITY AND COMPLICATIONS (VALONC PROJECT)

PD679

PROGNOSTIC VALUE OF RECTUS FEMORIS ULTRASOUND IN LUNG CANCER: SEX DIFFERENCES AND ASSOCIATION WITH MORTALITY AND COMPLICATIONS (VALONC PROJECT)

M. GONZALEZ PACHECO^1,*, J. M. Romero-Márquez², R. Fernández-Jiménez³, A. Carmona-Llanos⁴, M. T. Zarco-Martín⁵, J. M. García-Almeida³

¹Department of Endocrinology and Nutrition, Puerta del Mar University Hospital, Cádiz, ²Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, ³Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, ⁴Department of Endocrinology and Nutrition, Jerez de la Frontera University Hospital, Jerez de la Frontera, ⁵Department of Endocrinology and Nutrition, San Cecilio University Hospital, Granada, Spain

Rationale: Lung cancer remains associated with high morbidity and mortality despite therapeutic advances, and additional prognostic markers are needed. We evaluated the usefulness of rectus femoris ultrasound parameters as predictors of mortality and complications, considering potential sex-related differences.

Methods: Multicenter study including 373 patients with lung cancer from 13 hospitals. Rectus femoris ultrasound was performed in the supine position using a 10–12 MHz linear probe, measuring circumference (RF-CIR), cross-sectional area (RF-CSA), and X/Y axes. Associations with mortality were assessed using Cox proportional hazards models and associations with complications using logistic regression, in sex-stratified models adjusted for age and BMI. Prognostic cut-off points were identified and confirmed by Kaplan–Meier analysis.

Results: In sex-stratified models adjusted for age and BMI, ultrasound parameters were associated with mortality and complications. In men, Y-axis was associated with lower mortality (HR 0.31; 95% CI 0.10–0.90) and fewer complications (OR 0.32; 95% CI 0.11–0.91). In addition, RF-CSA (OR 0.68; 95% CI 0.52–0.89), RF-CIR (OR 0.63; 95% CI 0.46–0.85), and X-axis (OR 0.49; 95% CI 0.26–0.88) were inversely associated with complications. In women, X-axis was associated with lower mortality (HR 0.39; 95% CI 0.18–0.87), whereas Y-axis was associated with fewer complications (OR 0.06; 95% CI 0.00–0.49). Cut-off points of 0.86 cm for Y-axis in men and 2.1 cm for X-axis in women were identified and confirmed by Kaplan–Meier analysis (p<0.001 and p=0.007, respectively).

Conclusion: Rectus femoris ultrasound showed prognostic value in patients with lung cancer, with sex-specific associations for mortality and complications. These findings support its usefulness as a complementary tool for prognostic stratification.

Disclosure of Interest: M. GONZALEZ PACHECO Grant / Research Support from: This study received financial support from Fresenius Kabi., J. M. Romero-Márquez Grant / Research Support from: This study received financial support from Fresenius Kabi, R. Fernández-Jiménez Grant / Research Support from: This study received financial support from Fresenius Kabi, A. Carmona-Llanos Grant / Research Support from: This study received financial support from Fresenius Kabi, M. T. Zarco-Martín Grant / Research Support from: This study received financial support from Fresenius Kabi, J. M. García-Almeida Grant / Research Support from: This study received financial support from Fresenius Kabi