PD084 - PREVALENCE OF BODY COMPOSITION ALTERATIONS IN PATIENTS AT MODERATE-TO-HIGH RISK OF PULMONARY HYPERTENSION.

PD084

PREVALENCE OF BODY COMPOSITION ALTERATIONS IN PATIENTS AT MODERATE-TO-HIGH RISK OF PULMONARY HYPERTENSION.

G. Rentería-Serralde^1,2, A. Orea-Tejeda², D. González-Islas², S. Alday-Ramírez², G. Benítez-Moya², E. Vargas-Corona², J. De la Borda-Paredes², L. Ramírez-Morales², D. Bonilla-Cuatepotzo², K. García-Díaz², V. Maldonado-Vargas², G. Cruz Gijón^2,*, B. Valderrábano-Salas², J. Ruan-Díaz², R. Sánchez-Santillán²

¹Centro Interdisciplinario de Ciencias de la Salud, Unidad Milpa Alta, Instituto Politécnico Nacional, ²Unidad Clínica de Investigación Cardiopulmonar y Metabólica, Servicio de Cardiología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Ciudad de México, Mexico

Rationale: Pulmonary hypertension (PH) causes cardiac and pulmonary deterioration.(1)Patients had reduced lean mass, respiratory strength and endurance, increased body fat, a higher cardiac complications and risk of mortality.The prevalence of body composition alterations remains uncertain.(2)Our aim was determining the prevalence of body composition abnormalities in patients at moderate-to-high risk of PH.

Methods: A cross-sectional study.A total of 252 patients >18 years with moderate-to-high risk of PH(maximum tricuspid regurgitation velocity >2.9) were included.Patients hospitalized in the < 3 months were excluded.Body composition was assessed by bioimpedance.Dynapenia,muscle wasting,and sarcopenia were defined according to EWGSOP2 guidelines,and pulmonary function was evaluated by spirometry.The comparison between the study groups was performed using x² for qualitative variables and t-student for quantitative variables.

Results: A total of 252 patients were evaluated,47.61% were women.The mean age was 66.85±12.71, 50% had systemic hypertension,38% COPD,41% ILD, 84% HF,79% abdominal obesity,33% muscle wasting,and 45% dynapenia.Women showed a higher prevalence of hypertension (57% vs 44%, p=0.042),lower nephropathy(1% vs 14%, p<0.001), FEV₁(1.22±0.43 vs 1.58±0.66, p=0.002),and FVC(1.85±0.55 vs 2.53±0.69, p<0.001)compared to men. Regarding body composition, women had a higher prevalence of sarcopenia(16% vs 5%, p=0.007) and abdominal obesity (90% vs 70%, p<0.001),and lower muscle wasting(25% vs 41%, p=0.013)compared to men.

Image:

Conclusion: In patients with moderate-to-high risk of PH, sarcopenia and abdominal obesity are more prevalent in women and may be associated with a worse prognosis.

References: 1.Franquiz WB, et al. Hipertensión pulmonar. Medicine. 2022;13(68):3979–89

2.Breda AP, et al. Skeletal muscle abnormalities in pulmonary arterial hypertension. PLoS One 2014;9(12):e114101

Disclosure of Interest: None declared