P992 - EXPLORING GUT MICROBIOTA PROFILES IN RESISTANT HYPERTENSION: A CROSS-SECTIONAL ANALYSIS

P992

EXPLORING GUT MICROBIOTA PROFILES IN RESISTANT HYPERTENSION: A CROSS-SECTIONAL ANALYSIS

T. P. Minari^1,*, L. A. B. Fernandes², M. J. Humsi², J. C. Yugar-toledo², L. N. Cosenso-Martin ², L. P. Pisani¹, J. F. Vilela-martin ²

¹Bioscience, Federal University of São Paulo (UNIFESP), Santos, ²Hypertension, State Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil

Rationale: The study investigates the underexplored relationship between gut microbiota composition and resistant hypertension (RHT), a condition linked to significant cardiovascular risks. Understanding this relationship could provide insights into the role of intestinal dysbiosis in hypertension management.

Methods: A cross-sectional study was conducted with 17 normotensive (NT), 24 controlled hypertensive (CHT), and 22 RHT individuals aged 40–70 years. Nutritional, biochemical, stool parameters, and peripheral hemodynamic measures were evaluated. Median blood pressures and additional metrics, such as BMI and waist circumference, were assessed to determine significant group differences. Numerical variables were compared using ANOVA or Kruskal-Wallis tests, followed by Bonferroni-adjusted pairwise comparisons if differences were significant. P<0.05 was adopted.

Results: RHT individuals exhibited higher systolic blood pressure, BMI, and waist circumference compared to NT and CHT groups (P < 0.05). Microbiota analysis identified a higher prevalence of Prevotella in hypertensive individuals, with Eubacterium coprostanoligenes and Clostridium stricto sensu 1 being more abundant in RHT. Interestingly, NT showed a higher Firmicutes/Bacteroidetes ratio than hypertensive groups, suggesting varying levels of dysbiosis.

Conclusion: Alterations in gut microbiota composition, including a higher prevalence of Firmicutes in NT and reduced Fusicatenibacter in RHT, highlight potential contributors to intestinal dysbiosis in hypertension. Prevotella's increased abundance in CHT and RHT underscores an imbalance in the microbiota of hypertensive patients, offering new perspectives for clinical practice.

Disclosure of Interest: None declared