PD385 - ELEVATED BODY ROUNDNESS INDEX AND DYSLIPIDEMIA ARE ASSOCIATED WITH REDUCED KIDNEY FUNCTION: A POPULATION-BASED STUDY IN BRAZIL

PD385

ELEVATED BODY ROUNDNESS INDEX AND DYSLIPIDEMIA ARE ASSOCIATED WITH REDUCED KIDNEY FUNCTION: A POPULATION-BASED STUDY IN BRAZIL

H. Xavier Martins Mendonça^1,*, M. Cattafesta¹, C. B. do Prado², V. M. Muniz¹, L. B. Salaroli¹

¹Postgraduate Program in Nutrition and Health, ²Postgraduate Program in Public Health, Federal University of Espírito Santo, Vitória, Brazil

Rationale: The body roundness index (BRI) has emerged as a novel anthropometric indicator of body adiposity and cardiometabolic risk and is considered more accurate than the body mass index (BMI) for estimating visceral fat and adipose tissue. In addition to its metabolic implications, excess adiposity and dyslipidemia have been associated with impaired kidney function. However, the relationship between BRI, lipid profile alterations, and renal function remains insufficiently explored in population-based settings, particularly in the Brazilian context. This study aimed to investigate the association between BRI, a composite lipid profile score, and kidney function in adults.

Methods: Cross-sectional analysis of the National Health Survey (2013). BRI was calculated from waist circumference and height and classified as elevated (≥3.965 men; ≥3.757 women). A lipid score (0–3) was based on low HDL, high LDL, and high total cholesterol, according to cut-offs from the Brazilian Society of Cardiology. Renal function was assessed by estimated glomerular filtration rate (< 60 mL/min/1,73 m²). Associations were assessed using survey-weighted ordinal logistic regression models, adjusted for age, sex, race/skin color, and smoking. The NHS and the present study were approved by ethics committees (No. 328,159; 6,420,963). Stata version 17.0 was used, p < 0.05.

Results: Among 6,221 individuals (mean age 28.2 years), those with both elevated BRI and higher lipid profile scores (2 or 3 altered parameters) had lower estimated glomerular filtration rate (β = −4.17; 95% CI: −6.87 to −1.47 and β = −4.65; 95% CI: −8.35 to −0.94, respectively), independent of covariates.

Conclusion: Higher combined adiposity (elevated BRI) and dyslipidemia are associated with lower estimated glomerular filtration rate, supporting the role of multimorbidity in chronic kidney disease risk.

Disclosure of Interest: None declared