Sep 14, 2025
1:00 PM2:00 PM
Poster Session
P389 - EXOCRINE PANCREATIC INSUFFICIENCY IS NOT A DIFFERENTIATING CRITERION BETWEEN NON-MALNOURISHED AND MALNOURISHED PANCREATIC ADENOCARCINOMA PATIENTS
P389
EXOCRINE PANCREATIC INSUFFICIENCY IS NOT A DIFFERENTIATING CRITERION BETWEEN NON-MALNOURISHED AND MALNOURISHED PANCREATIC ADENOCARCINOMA PATIENTS
Y. M. M. Dupertuis1,*, B. Zidi1, A. Hemmer1, V. A. Bertoni Maluf1, V. Lazarevic2, J. Schrenzel2, T. Koessler3, L. Genton1
1Geneva University Hospitals, Clinical Nutrition, 2Geneva University Hospitals, Genomic Research Laboratory, 3Geneva University Hospitals, Medical Oncology, Geneva, Switzerland
Rationale: Nutritional risk is especially prevalent in pancreatic adenocarcinoma patients (PA). We have previously shown that body weight loss and inflammatory state are the GLIM criteria that differentiate malnourished vs. non-malnourished PA patients. This study aimed to evaluate whether exocrine pancreatic insufficiency (EPI) explains the higher body weight loss in malnourished patients.
Methods: Newly diagnosed PA, naïve of oncology treatment and long-term artificial nutrition, were classified into malnourished and non-malnourished patients using the GLIM criteria. Reduced muscle mass was assessed by bioelectrical impedance analysis, appetite by a visual analogue scale, energy need coverage by indirect calorimetry (Q-NRG®) and a 3-day dietary record (energy intake x 100 / 1.24*REE). A fecal sample and a blood test were taken after an overnight fasting to measure fecal elastase and other biological parameters, respectively. Data were analyzed with unpaired t-test after normality and heteroscedasticity verification.
Results: Fecal elastase was not different between PA malnourished patients and non-malnourished patients (Table). Malnourished patients had a lower BMI (p=.05), and lower blood glucose levels (p=.002). No significant differences were observed for the HOMA-IR score and other biological parameters.
|
Age (y) |
Fecal elastase (µg/g) |
Blood glucose (%) |
HOMA-IR score |
ASAT (IU/L) |
ALAT (IU/L) |
|
Normal range |
|
≥ 200 |
< 6 |
< 6 |
< 50 |
< 50 |
|
Non-malnourished PA (n=6) |
66 ± 5 |
190 ± 65 |
8.2 ± 1.0 |
5.3 ± 1.3 |
19 ± 2 |
22 ± 3 |
|
Malnourished PA (n=10) |
65 ± 4 |
154 ± 50 |
6.4 ± 0.2 |
2.6 ± 0.9 |
51 ± 12 |
60 ± 15 |
|
Significance (p) |
0.872 |
0.671 |
0.002 |
0.095 |
0.063 |
0.077 |
Conclusion: Compared to non-malnourished, malnourished PA patients had no significant decrease in fecal elastase levels. This suggests that EPI is not the primary cause of body weight loss in those patients. These results need to be confirmed in a larger group of patients.
Disclosure of Interest: None declared