PD1037 - THE WHOLE-COURSE OF SUPERVISED HOME-BASED MULTI-MODAL PREHABILITATION TO IMPROVE CLINICAL OUTCOME IN PATIENTS UNDERGOING NEOADJUVANT CHEMOTHERAPY PRIOR TO GASTRECTOMY: A SINGLE-CENTER RANDOMIZED CONTROLLED TRIAL
PD1037
THE WHOLE-COURSE OF SUPERVISED HOME-BASED MULTI-MODAL PREHABILITATION TO IMPROVE CLINICAL OUTCOME IN PATIENTS UNDERGOING NEOADJUVANT CHEMOTHERAPY PRIOR TO GASTRECTOMY: A SINGLE-CENTER RANDOMIZED CONTROLLED TRIAL
Y. Tian1, Q. Liu1, Y. Zhou1,*, Z. Niu1
1the affiliated hospital of qingdao university, Qingdao, China
Rationale: The toxic side effects and decline in physical function that accompany chemotherapy increase the difficulty of perioperative management and may lead to adverse clinical outcomes in patients undergoing surgical treatment.
Methods: An open-label, Phase II, single-center randomized clinical trial was conducted in the Affiliated Hospital of Qingdao University. Patients with advanced gastric cancer who were planned to undergo gastrectomy after neoadjuvant chemotherapy were randomly assigned to the study group (multi-modal prehabilitation) or the control group. The multimodal prehabilitation program, comprising exercise, nutritional support, and psychological intervention. The primary endpoint was the functional fitness between neoadjuvant chemotherapy and preoperative time point.
Results: Between July 2024 and January 2025, 85 participants were included in the intention-to-treat (ITT) population. Compared with the control group, prehabilitation had alleviated the attenuation of cardiopulmonary fitness during neoadjuvant chemotherapy and improved the fitness prior to surgery. Prehabilitation resulted in higher adherence to neoadjuvant chemotherapy, better nutritional status, and superior quality of life. Patients in the study group exhibited a significantly lower incidence of postoperative pneumonia, a reduced rate of Clavien-Dindo grade II complications, as well as faster postoperative functional recovery and a shorter length of hospital stay.
Conclusion: The whole course of supervised, home-based multi-modal prehabilitation improves functional capacity prior to gastrectomy, which attenuates the adverse reaction of neoadjuvant chemotherapy. Improved physical, psychological, and nutritional status preoperatively may translate to better postoperative outcomes.
Disclosure of Interest: None declared