PD724 - IMPACT AND ASSESSMENT OF NUTRITIONAL STATUS AND SYSTEMIC INFLAMMATORY RESPONSE ON POSTOPERATIVE OUTCOMES IN COLORECTAL CANCER PATIENTS

PD724

IMPACT AND ASSESSMENT OF NUTRITIONAL STATUS AND SYSTEMIC INFLAMMATORY RESPONSE ON POSTOPERATIVE OUTCOMES IN COLORECTAL CANCER PATIENTS

I. Pantic^1,*, M. Sibinović¹, M. Bezmarević²

¹General surgery, ²Department of Hepatobiliary and Pancreatic Surgery, Clinic for General Surgery, Military medical academy , Belgrade , Serbia

Rationale: Colorectal cancer (CRC) is one of the most common malignancies of the gastrointestinal tract, and patients nutritional status plays a crucial role in postoperative recovery.

This study aimed to evaluate the impact of preoperative nutritional status and systemic inflammatory response on postoperative outcomes in patients undergoing surgery for CRC.

Methods: A prospective observational study was conducted at the Military Medical Academy, including 50 patients operated for CRC between January 2024 and March 2025. Nutritional status was assessed using BMI, Nutritional Risk Screening (NRS-2002), and Subjective Global Assessment (SGA), while inflammatory status was monitored via the Modified Glasgow Prognostic Score (mGPS). Postoperative outcomes focused on the length of hospitalization (LOH) and complications (Clavien-Dindo classification). Statistical analysis included t-tests, ANOVA, and correlation coefficients.

Results: The average length of hospitalization was 9.1 days (range: 6–14). A statistically significant association was found between BMI and LOH (p < 0.05), with a negative correlation suggesting slower recovery in patients with lower BMI. NRS-2002 scores also showed a highly significant association with the duration of postoperative stay (p < 0.05), where patients with higher nutritional risk (NRS-2002 ≥ 3) experienced prolonged stays. The strongest positive correlation was observed between the mGPS inflammatory score and LOH (r = 0.3239), indicating that a heightened systemic inflammatory response significantly delays recovery.

Conclusion:  This study confirms the importance of early nutritional screening and individualized nutritional support in reducing postoperative complications and enhancing the quality of life for CRC patients.

Disclosure of Interest: None declared