P810 - DIETARY PATTERNS AND ENDOGENOUS TESTOSTERONE, ESTRADIOL, AND SEX HORMONE-BINDING GLOBULIN: A POPULATION-BASED STUDY

P810

DIETARY PATTERNS AND ENDOGENOUS TESTOSTERONE, ESTRADIOL, AND SEX HORMONE-BINDING GLOBULIN: A POPULATION-BASED STUDY

M. Amiri^1,*, M. Steur², T. Muka³, L. Chaker¹, T. Voortman¹

¹Department of Epidemiology, Erasmus Medical Center (MC), Rotterdam, ²Division of Human Nutrition and Health, Wageningen University & Research, wageningen , Netherlands, ³Epistudia, Bern, Switzerland

Rationale: Endogenous sex hormones play key roles in physiological systems and chronic disease development. Also, sex hormone-binding globulin (SHBG), a glycoprotein that binds androgens and estrogens, may influence disease risk independently of hormones. While diet can affect hormone levels, the impact of overall dietary patterns remains unclear. We studied the associations between plant-based dietary indexes (PDI) and the Mediterranean Diet (MedDiet) with total testosterone (TT), free testosterone (FT), estradiol (E2), and SHBG.

Methods: We studied cross-sectional associations of PDI, healthy (hPDI), unhealthy (uPDI) PDI and MedDiet with TT, FT, E2 and SHBG in 3035 men and 4126 women in the Rotterdam Study. For E2 in women, only naturally postmenopausal women not using hormone replacement therapy were included (n=2306). Multivariable linear regression models adjusted for potential confounders were implemented and beta estimates and 95% confidence intervals were generated.

Results: In men, higher PDI was associated with 0.42 nmol/L higher TT, 1.53 pmol/L lower E2, and 1.57 nmol/L higher SHBG. Higher hPDI score was associated with lower E2 and higher SHBG. Higher MedDiet was associated with 0.42 nmol/L higher TT, 0.13 ng/dL higher FT, and 0.83 nmol/L higher SHBG but not with E2. In women, higher hPDI and MedDiet scores were associated with lower FT, and higher PDI, hPDI, and uPDI scores were associated with 1.86, 2.04, and 1.30 nmol/L higher SHBG levels (Fig 1).

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Conclusion: These findings suggest that dietary patterns, particularly PDI, may favorably influence sex hormones and SHBG. Given their links to disease, this findings may have implications for the role of diet in disease risk through hormonal pathways. Longitudinal studies are needed to confirm these associations and their impact on disease outcomes.

Disclosure of Interest: None declared